Medline ® Abstract for Reference 82
of 'Clinical features and diagnosis of restless legs syndrome/Willis-Ekbom disease and periodic limb movement disorder in adults'
82
TI
Charcot-Marie-Tooth disease type 2 with restless legs syndrome.
AU
Gemignani F, Marbini A, Di Giovanni G, Salih S, Terzano MG
SO
Neurology. 1999 Mar;52(5):1064-6.
In a series of 44 consecutive patients with Charcot-Marie-Tooth disease (CMT), we found restless legs syndrome (RLS) in 10 of 27 CMT type 2 (CMT2) patients (37%) and in none of 17 CMT type 1 patients (p = 0.004). In the CMT2 patients, RLS was associated with positive sensory symptoms (10/10 versus 10/17; p = 0.026). This finding supports the view that a disorder of sensory input plays a role in the pathogenesis of RLS. Symptomatic treatment may benefit these patients.
AD
Institute of Neurology, University of Parma, Italy.
PMID