Medline ® Abstract for Reference 12
of 'Clinical features and diagnosis of restless legs syndrome/Willis-Ekbom disease and periodic limb movement disorder in adults'
12
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Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome.
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Earley CJ, Connor JR, Beard JL, Malecki EA, Epstein DK, Allen RP
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Neurology. 2000;54(8):1698.
CSF and serum were obtained from 16 patients with idiopathic restless legs syndrome (RLS) and 8 age-matched healthy control subjects. Patients with RLS had lower CSF ferritin levels (1. 11 +/- 0.25 ng/mL versus 3.50 +/- 0.55 ng/mL; p = 0.0002) and higher CSF transferrin levels (26.4 +/- 5.1 mg/L versus 6.71 +/- 1.6 mg/L; p = 0.018) compared with control subjects. There was no difference in serum ferritin and transferrin levels between groups. The presence of reduced ferritin and elevated transferrin levels in CSF is indicative of low brain iron in patients with idiopathic RLS.
AD
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA.
PMID