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Clinical features and diagnosis of malabsorption

Authors
Joel B Mason, MD
Vladan Milovic, MD, PhD
Section Editor
Timothy O Lipman, MD
Deputy Editor
Shilpa Grover, MD, MPH

INTRODUCTION

Malabsorption refers to impaired absorption of nutrients [1]. It can result from congenital defects in the membrane transport systems of the small intestinal epithelium or from acquired defects in the epithelial absorptive surface. Another factor that can interfere with nutrient absorption is maldigestion, which is due to impaired digestion of nutrients within the intestinal lumen or at the terminal digestive site of the brush border membrane of mucosal epithelial cells.

Although malabsorption and maldigestion are pathophysiologically different, the processes underlying digestion and absorption are interdependent. As a result, in clinical practice the term malabsorption has come to denote derangements in both processes.

Three steps are required for normal nutrient absorption [1]:

Luminal and brush border processing

Absorption into the intestinal mucosa

                      

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Literature review current through: Nov 2016. | This topic last updated: Tue May 03 00:00:00 GMT+00:00 2016.
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