Classification of primary cutaneous lymphomas
- Rein Willemze, MD
Rein Willemze, MD
- Professor and Chairman, Department of Dermatology
- Leiden University Medical Center
Primary cutaneous lymphomas are a heterogeneous group of T cell and B cell neoplasms that present in the skin without any evidence of extracutaneous disease at the time of diagnosis. In the last two decades, multiple classification systems have been used for these conditions. These include:
●European Organization for Research and Treatment of Cancer (EORTC) classification
●World Health Organization (WHO) classification 2001
●WHO-EORTC classification 2005
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- Willemze R, Jansen PM, Cerroni L, et al. Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases. Blood 2008; 111:838.
- CUTANEOUS T CELL LYMPHOMAS
- Mycosis fungoides
- Sézary syndrome
- Adult T cell leukemia-lymphoma
- Primary cutaneous CD30+ lymphoproliferative disorders
- Subcutaneous panniculitis-like T cell lymphoma
- Extranodal NK/T cell lymphoma, nasal type
- Primary cutaneous peripheral T cell lymphoma, rare subtypes
- - Primary cutaneous gamma-delta T cell lymphoma
- - Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T cell lymphoma
- - Primary cutaneous acral CD8+ T cell lymphoma
- - Primary cutaneous CD4+ small/medium T cell lymphoproliferative disorder
- CUTANEOUS B CELL LYMPHOMAS
- Primary cutaneous marginal zone lymphoma
- Primary cutaneous follicle center lymphoma
- Primary cutaneous diffuse large B cell lymphoma, leg type