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Medline ® Abstract for Reference 65

of 'Chronic functional constipation and fecal incontinence in infants and children: Treatment'

Efficacy and optimal dose of daily polyethylene glycol 3350 for treatment of constipation and encopresis in children.
Pashankar DS, Bishop WP
J Pediatr. 2001;139(3):428.
OBJECTIVE: To determine efficacy, safety, and optimal dose of a laxative, polyethylene glycol (PEG) 3350, in children with chronic constipation.
STUDY DESIGN: Children with chronic constipation (n = 24) were treated with PEG for 8 weeks at an initial dose of 1 g/kg/d. The dose was adjusted every 3 days as required to achieve 2 soft stools per day. A diary was kept to monitor dose, stool frequency and consistency, soiling, and other symptoms. Stool consistency was rated from 1 (hard) to 5 (watery). Subjects were examined for fecal retention. The Student t test and the Fisher exact test were used for data analysis.
RESULTS: All 20 children who completed the study found PEG to be palatable and were satisfied with the treatment. There were no significant adverse effects. Weekly stool frequency increased from 2.3 +/- 0.4 to 16.9 +/- 1.6 (P<.0001) during treatment and stool consistency from 1.2 +/- 0.1 to 3.3 +/- 0.1 (P<.0001). In 9 children with soiling, weekly soiling events declined from 10.0 +/- 2.4 to 1.3 +/- 0.7 (P =.003). The mean effective dose was 0.84 g/kg/d (range, 0.27-1.42 g/kg/d).
CONCLUSION: Daily administration of PEG at a mean dose of 0.8 g/kg is an effective, safe, and palatable treatment for constipation.
Division of Gastroenterology, Department of Pediatrics, University of Iowa College of Medicine, Iowa City, USA.