Medline ® Abstract for Reference 33
of 'Chronic functional constipation and fecal incontinence in infants and children: Treatment'
Polyethylene glycol: a game-changer laxative for children.
Alper A, Pashankar DS
J Pediatr Gastroenterol Nutr. 2013;57(2):134.
Constipation is a common problem in children worldwide. It can also be a chronic problem persisting for many months to years. Successful treatment of constipation requires long-term use of laxatives. Commonly used laxatives in children include milk of magnesia, lactulose, mineral oil, and polyethylene glycol. Compared with other laxatives, polyethylene glycol (with and without electrolytes) is a relatively new laxative used during the last decade. Recent studies report excellent efficacy and safety of polyethylene glycol for the long-term treatment of constipation in children. Because of excellent patient acceptance, polyethylene glycol has become a preferred choice of laxative for many practitioners. This article reviews the recently published pediatric literature on biochemistry, efficacy, safety, patient acceptance, and pharmacoeconomics of polyethylene glycol.
Department of Pediatrics, Division of Pediatric Gastroenterology, Yale University School of Medicine, New Haven, CT 06520, USA.