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Medline ® Abstract for Reference 33

of 'Chronic functional constipation and fecal incontinence in infants and children: Treatment'

33
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Polyethylene glycol: a game-changer laxative for children.
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Alper A, Pashankar DS
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J Pediatr Gastroenterol Nutr. 2013;57(2):134.
 
Constipation is a common problem in children worldwide. It can also be a chronic problem persisting for many months to years. Successful treatment of constipation requires long-term use of laxatives. Commonly used laxatives in children include milk of magnesia, lactulose, mineral oil, and polyethylene glycol. Compared with other laxatives, polyethylene glycol (with and without electrolytes) is a relatively new laxative used during the last decade. Recent studies report excellent efficacy and safety of polyethylene glycol for the long-term treatment of constipation in children. Because of excellent patient acceptance, polyethylene glycol has become a preferred choice of laxative for many practitioners. This article reviews the recently published pediatric literature on biochemistry, efficacy, safety, patient acceptance, and pharmacoeconomics of polyethylene glycol.
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Department of Pediatrics, Division of Pediatric Gastroenterology, Yale University School of Medicine, New Haven, CT 06520, USA.
PMID