Medline ® Abstract for Reference 32
of 'Chronic functional constipation and fecal incontinence in infants and children: Treatment'
Tween 80/diatrizoate enemas in bowel obstruction.
Wood BP, Katzberg RW
AJR Am J Roentgenol. 1978;130(4):747.
Although successful treatment of meconium ileus with Gastrografin enema has been attributed to the hypertonicity of this material, Tween 80, present in a 0.75% concentration, may be its most effective component. Tween 80 acts as a surface-active substance and stool emulsifier. An enema solution of 1%-2% Tween 80 and isotonic sodium diatrizoate has been effective in the relief of meconium or fecal mass obstruction in infants and children.