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Medline ® Abstract for Reference 98

of 'Chemotherapy hepatotoxicity and dose modification in patients with liver disease'

Commentary: Oncologic drugs in patients with organ dysfunction: a summary.
Superfin D, Iannucci AA, Davies AM
Oncologist. 2007;12(9):1070.
There are few prospective data regarding the pharmacokinetics and clinical toxicity of commonly used chemotherapeutics in cancer patients with organ dysfunction. Although increasing numbers of studies are investigating newer chemotherapeutics in patients with liver or kidney dysfunction, most guidelines for dosing, especially for established agents, remain empiric. This review describes the available data (both prospective and case study) evaluating the impact of renal and hepatic dysfunction on toxicity and dosing of commonly used chemotherapeutics and provides a practical summary for their use in this setting.
University of California Davis Cancer Center, 4501 X Street, Sacramento, California 95817, USA.