Medline ® Abstract for Reference 42
of 'Chemotherapy hepatotoxicity and dose modification in patients with liver disease'
Goldberg JW, Lidsky MD
South Med J. 1985;78(2):222.
Cyclophosphamide, a potent alkylating agent, is effective therapy for some rheumatic diseases. Despite primary hepatic activation of the drug, hepatic toxicity has been reported only in one case. We have reported two episodes of hepatic dysfunction associated with oral cyclophosphamide administration in patients with systemic rheumatic diseases.