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Medline ® Abstract for Reference 198

of 'Chemotherapy hepatotoxicity and dose modification in patients with liver disease'

Clinical studies of Platinum Coordination compounds in the treatment of various malignant diseases.
Hill JM, Loeb E, MacLellan A, Hill NO, Khan A, King JJ
Cancer Chemother Rep. 1975;59(3):647.
Following the prior work of Rosenberg et al, Rosenberg and VanCamp, and Speer et al, we started clinical trials with cis-dichlorodiammineplatinum(II) in April 1971. Marked tumor regression was noted in several malignant diseases in these initial clinical studies which were reported at the Chemotherapy Congress in Prague, August 1971. At the present time over 178 patients have been treated wihhis durg for a variety of malignant conditions. Approximately half of these patients received the platinum compound alone and the other half received it in combination with four other chemotherapeutic agents...