Medline ® Abstract for Reference 14
of 'Chemotherapy hepatotoxicity and dose modification in patients with liver disease'
Hepatic veno-occlusive disease caused by 6-thioguanine.
Gill RA, Onstad GR, Cardamone JM, Maneval DC, Sumner HW
Ann Intern Med. 1982;96(1):58.
Clinically reversible veno-occlusive disease of the liver developed in a 23-year-old man with acute lymphocytic leukemia after 10 months of maintenance therapy with 6-thioguanine. Serial liver biopsies showed the development and resolution of intense sinusoidal engorgement. Although this disease was clinically reversible, some subintimal fibrosis about the terminal hepatic veins persisted. This case presented a unique opportunity to observe the histologic features of clinically reversible hepatic veno-occlusive disease over time, and may be the first case of veno-occlusive related solely to 6-thioguanine.