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Medline ® Abstract for Reference 117

of 'Chemotherapy hepatotoxicity and dose modification in patients with liver disease'

117
TI
Hepatocellular carcinoma in a long-term survivor of acute lymphocytic leukemia.
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Fried M, Kalra J, Ilardi CF, Sawitsky A
SO
Cancer. 1987;60(10):2548.
 
Hepatocellular carcinoma (HCC) occurred in a 28-year-old woman treated for acute lymphocytic leukemia (ALL) with methotrexate (MTX) and 6-mercaptopurine (6-MP), off all therapy for 15 years, who was also heterozygous for alpha-1 antitrypsin (alpha-1 AT) deficiency. MTXD is responsible for the development of HCC in this patient. The literature concerning the incidence of HCC in patients treated with MTX and 6-MP and in alpha-1 antitrypsin deficiencies is reviewed.
AD
Department of Medicine, Queens Hospital Center, Jamaica, NY 1142.
PMID