Medline ® Abstract for Reference 112
of 'Chemotherapy hepatotoxicity and dose modification in patients with liver disease'
6-thioguanine as a cause of toxic veno-occlusive disease of the liver.
Satti MB, Weinbren K, Gordon-Smith EC
J Clin Pathol. 1982;35(10):1086.
Lesions of hepatic veno-occlusive disease were found in the needle biopsy specimen of one patient suffering from chronic granulocytic leukaemia and in the liver at necropsy of a second patient suffering from acute myeloid leukaemia. The treatment included administration of 6-thioguanine which was the only relevant compound used in the first patient and which was combined with cytosine arabinoside in the second patient.