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Medline ® Abstract for Reference 112

of 'Chemotherapy hepatotoxicity and dose modification in patients with liver disease'

112
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6-thioguanine as a cause of toxic veno-occlusive disease of the liver.
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Satti MB, Weinbren K, Gordon-Smith EC
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J Clin Pathol. 1982;35(10):1086.
 
Lesions of hepatic veno-occlusive disease were found in the needle biopsy specimen of one patient suffering from chronic granulocytic leukaemia and in the liver at necropsy of a second patient suffering from acute myeloid leukaemia. The treatment included administration of 6-thioguanine which was the only relevant compound used in the first patient and which was combined with cytosine arabinoside in the second patient.
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PMID