Medline ® Abstract for Reference 108
of 'Chemotherapy hepatotoxicity and dose modification in patients with liver disease'
Probable azathioprine hepatotoxicity: a case report.
Small P, Lichter M
Ann Allergy. 1989;62(6):518.
A patient with polymyositis was treated initially with corticosteroids. Subsequently, azathioprine was added but was associated with transient hepatotoxicity on two separate occasions, 6 months apart. Both episodes occurred 3 weeks after starting the latter drug. This is the first case of azathioprine toxicity documented by both histopathology and drug challenge.
Division of Allergy and Clinical Immunology, SMBD-Jewish General Hospital, Montreal, Quebec, Canada.