Characteristics of antiemetic drugs
- George F Longstreth, MD
George F Longstreth, MD
- Voluntary Clinical Professor of Medicine
- University of California San Diego School of Medicine
- Paul J Hesketh, MD
Paul J Hesketh, MD
- Section Editor — Supportive Care
- Chair, Lahey Health Cancer Institute
- Director, Thoracic Oncology, Lahey Hospital and Medical Center
- Professor of Medicine, Tufts University School of Medicine
Several classes of antiemetic drugs are available that antagonize the neurotransmitter receptors known to be involved in the physiology of nausea and vomiting. The antiemetic drugs are classified according to their primary action; some agents affect multiple receptors.
Five neurotransmitter receptor sites are of primary importance in the vomiting reflex:
●M1 – muscarinic
●D2 – dopamine
●H1 – histamine
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- ANTICHOLINERGIC AGENTS
- DOPAMINE RECEPTOR ANTAGONISTS
- SEROTONIN RECEPTOR ANTAGONISTS
- 5-HT3 receptor antagonists
- NEUROKININ RECEPTOR ANTAGONISTS
- INFORMATION FOR PATIENTS
- SUMMARY AND RECOMMENDATIONS