Cervical intraepithelial neoplasia: Management of low-grade and high-grade lesions
- Jason D Wright, MD
Jason D Wright, MD
- Sol Goldman Associate Professor of Obstetrics and Gynecology
- Chief, Division of Gynecologic Oncology
- Columbia University College of Physicians and Surgeons
Cervical intraepithelial neoplasia (CIN) is a premalignant condition of the uterine cervix . The ectocervix (surface of the cervix that is visualized on vaginal speculum examination) is covered in squamous epithelium, and the endocervix, including the cervical canal, is covered with glandular epithelium. CIN refers to squamous abnormalities. Glandular cervical neoplasia includes adenocarcinoma in situ and adenocarcinoma. (See "Cervical cytology: Evaluation of atypical and malignant glandular cells" and "Cervical adenocarcinoma in situ" and "Invasive cervical adenocarcinoma".)
Screening tests for cervical cancer include cervical cytology and testing for oncogenic subtypes of human papillomavirus (HPV) (table 1). Follow-up of abnormalities in screening tests with colposcopy and cervical biopsy may result in a diagnosis of CIN, glandular neoplasia, or cervical cancer .
CIN may be low-grade or high-grade. Women with low-grade CIN have a low potential for developing cervical malignancy, while those with high-grade lesions are at high risk of progression to malignancy. In managing women with CIN, the goal is to prevent possible progression to invasive cancer while avoiding overtreatment of lesions that are likely to regress.
Management of CIN is reviewed here. Related issues are discussed separately:
●Treatment of CIN (see "Cervical intraepithelial neoplasia: Treatment and follow-up")
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- OVERVIEW OF MANAGEMENT
- Observation versus treatment
- See-and-treat protocols
- LOW-GRADE LESIONS: CIN 1
- Risk of malignant disease
- CIN 1 preceded by lesser abnormalities
- - Women ages 25 or older
- - Women ages 21 to 24
- CIN 1 preceded by ASC-H or HSIL
- - Women ages 25 and older
- - Women ages 21 to 24
- HIGH-GRADE LESIONS: CIN 2,3
- Risk of malignant disease
- Young women
- SPECIAL POPULATIONS
- Pregnant women
- Adolescents inadvertently screened
- Immunocompromised women
- INFORMATION FOR PATIENTS
- SUMMARY AND RECOMMENDATIONS