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Cervical adenocarcinoma in situ

INTRODUCTION

Adenocarcinoma in situ of the uterine cervix is a premalignant glandular condition. Adenocarcinoma in situ is the only known precursor to cervical adenocarcinoma, and appropriate management can prevent the occurrence of invasive disease in many cases [1]. The usual interval between clinically detectable adenocarcinoma in situ and early invasion appears to be at least five years, suggesting ample opportunity for screening and intervention [2,3].

Glandular neoplasia of the uterine cervix is less common than squamous neoplasia, comprising one quarter of all annual cervical cancers diagnoses in the United States [4]. Over the past few decades, however, the incidence of adenocarcinoma in situ and invasive adenocarcinoma has increased [5].

The diagnosis and management of cervical adenocarcinoma in situ are reviewed here. Related topics are discussed separately, including:

EPIDEMIOLOGY AND RISK FACTORS

The average age of women at diagnosis of cervical adenocarcinoma in situ (AIS) is 36.9 years, based upon a meta-analysis that included 33 studies with 1278 patients with a diagnosis of AIS on cervical cone biopsy [6].

                           

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Literature review current through: Aug 2014. | This topic last updated: May 8, 2013.
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