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Central neuropathic facial pain

Ivan Garza, MD
Section Editor
Jerry W Swanson, MD, MHPE
Deputy Editor
John F Dashe, MD, PhD


By definition, "central pain" is neuropathic pain caused by a lesion or dysfunction in the central nervous system. The clinical presentation can be quite variable among patients [1]. The current International Classification of Headache Disorders recognizes two entities that are central causes of facial pain [2]:

Central neuropathic pain attributed to multiple sclerosis

Central post-stroke pain

This topic will discuss these conditions. Other causes of facial pain are reviewed elsewhere. (See "Overview of craniofacial pain".)


A lesion at any level of the central nervous system from the spinal trigeminal nucleus or spinal dorsal horn to the cerebral cortex has the potential for causing central neuropathic facial pain. There may be a higher risk for developing central pain when the spinothalamic and quintothalamic pathways are affected, compared with suprathalamic lesions [1].

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Literature review current through: Nov 2017. | This topic last updated: Oct 06, 2017.
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