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Medline ® Abstract for Reference 27

of 'Cellular and molecular biology of chronic myeloid leukemia'

27
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Is it downhill from here? Eliminating leukemic stem cells and curing chronic myeloid leukemia.
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Smith CC, Shah NP
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Clin Cancer Res. 2011 Nov;17(21):6605-7. Epub 2011 Oct 25.
 
Patients with chronic phase chronic myeloid leukemia who respond to imatinib have a rapid initial decrease in BCR-ABL transcript levels (α), followed by a slow decline (β). The rate ofβdecrease is consistent with declining leukemic stem cells and may predict which patients may safely discontinue therapy.
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Division of Hematology-Oncology, Department of Medicine, University of California at San Francisco, San Francisco, California 94143, USA.
PMID