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Causes of neonatal cholestasis

Robert J Shulman, MD
Section Editors
Steven A Abrams, MD
Elizabeth B Rand, MD
Deputy Editor
Alison G Hoppin, MD


Neonatal cholestasis is defined serologically as the accumulation of components of bile in the bloodstream, most frequently manifested as conjugated hyperbilirubinemia in the newborn period. Cholestasis results from diminished bile flow and/or excretion, which can be the result of a number of different causes.

Causes of neonatal cholestasis can be divided into the following categories (table 1A):





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Literature review current through: Apr 2016. | This topic last updated: Apr 6, 2016.
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