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Causes and clinical manifestations of primary adrenal insufficiency in children

Author
Patricia A Donohoue, MD
Section Editor
Mitchell E Geffner, MD
Deputy Editor
Alison G Hoppin, MD

INTRODUCTION

Adrenal insufficiency is defined by the impaired synthesis and release of adrenocortical hormones. It is classified based upon the mechanism:

Primary adrenal insufficiency results from disease intrinsic to the adrenal cortex.

Central adrenal insufficiency can be caused by impaired production or action of adrenocorticotropic hormone (ACTH). It can be caused by several mechanisms:

Secondary adrenal insufficiency is caused by impaired release from the pituitary gland or impaired ACTH effects.

Tertiary adrenal insufficiency results from the impaired release or effect of corticotropin releasing hormone (CRH) from the hypothalamus.

                                

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Literature review current through: Nov 2016. | This topic last updated: Tue Mar 08 00:00:00 GMT 2016.
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