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Cardiovascular sequelae of Kawasaki disease: Clinical features and evaluation

Jane W Newburger, MD, MPH
Sarah D de Ferranti, MD, MPH
David R Fulton, MD
Section Editor
John K Triedman, MD
Deputy Editor
Carrie Armsby, MD, MPH


Kawasaki disease (KD; also called mucocutaneous lymph node syndrome) is a vasculitis of unknown etiology that generally occurs in infancy and childhood. The acute illness is self-limited and is characterized by high fever, nonexudative conjunctivitis, inflammation of the oral mucosa, rash, cervical adenopathy, and findings in the extremities, including swollen hands and feet, red palms and soles, and, later, subungual peeling. (See "Kawasaki disease: Clinical features and diagnosis" and "Kawasaki disease: Epidemiology and etiology".)

Children with KD are at risk for serious cardiovascular sequelae, particularly coronary artery abnormalities (CAAs), which can lead to myocardial ischemia, infarction, and sudden death. The risk of developing CAAs is highest among children with KD who are not treated early in the disease with high-dose intravenous immune globulin (IVIG). Thus, initial management of patients with KD is focused on early diagnosis and treatment with IVIG. (See "Kawasaki disease: Initial treatment and prognosis".)

The clinical features and evaluation of cardiac sequelae of KD, including CAA, will be reviewed here. Other aspects of KD are discussed in greater detail separately:

(See "Cardiovascular sequelae of Kawasaki disease: Management and prognosis".)

(See "Kawasaki disease: Epidemiology and etiology".)

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Literature review current through: Oct 2017. | This topic last updated: Oct 05, 2017.
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