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Cardiotoxicity of anthracycline-like chemotherapy agents

Authors
Justin Floyd, DO
James P Morgan, MD, PhD
Stacey Berg, MD
Section Editors
Reed E Drews, MD
David G Poplack, MD
Stephen S Gottlieb, MD
Deputy Editor
Sadhna R Vora, MD

INTRODUCTION

Cancer patients who are undergoing chemotherapy have an increased risk of developing cardiovascular complications, and the risk is even greater if there is a known history of heart disease. Among the serious clinical cardiac complications that have been reported are:

Arrhythmias

Myocardial necrosis causing a dilated cardiomyopathy

Vasoocclusion or vasospasm resulting in angina or myocardial infarction

A wide range of chemotherapy agents have been associated with cardiotoxicity [1,2]. The anthracyclines and related compounds (doxorubicin, daunorubicin, idarubicin, epirubicin, and the anthraquinone mitoxantrone) are some of the most frequently implicated agents [3].

                                             

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Literature review current through: Nov 2016. | This topic last updated: Wed Dec 02 00:00:00 GMT+00:00 2015.
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