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Carbon monoxide poisoning

Peter F Clardy, MD
Scott Manaker, MD, PhD
Holly Perry, MD
Section Editors
Stephen J Traub, MD
Michele M Burns, MD, MPH
Deputy Editor
Jonathan Grayzel, MD, FAAEM


Carbon monoxide (CO) is an odorless, tasteless, colorless, nonirritating gas formed by hydrocarbon combustion. The atmospheric concentration of CO is generally below 0.001 percent, but it may be higher in urban areas or enclosed environments. CO binds to hemoglobin with much greater affinity than oxygen, forming carboxyhemoglobin (COHb) and resulting in impaired oxygen transport and utilization. CO can also precipitate an inflammatory cascade that results in CNS lipid peroxidation and delayed neurologic sequelae.

CO poisoning will be reviewed here. A summary table to facilitate emergent management is provided (table 1). Related topics including smoke inhalation and hyperbaric oxygen therapy are presented separately. (See "Hyperbaric oxygen therapy" and "Inhalation injury from heat, smoke, or chemical irritants".)


Fire-related smoke inhalation is responsible for most cases of carbon monoxide (CO) poisoning. Non-fire related CO poisoning is responsible for up to 50,000 emergency department (ED) visits and 1200 deaths per year, making it one of the leading causes of poisoning death in the United States [1-5]. Inadvertent, non-fire related CO poisoning likely causes around 400 deaths annually, while the number of intentional CO poisonings resulting in death is twice as high [1,4,6,7]. The case-fatality rate for non-fire CO poisoning ranges widely, but analysis of aggregated national data from the United States support an overall mortality of 1 to 3 percent [3,4,8,9]. The mortality rate is higher for intentional poisoning than for inadvertent exposure [4].

Unlike intentional poisoning, unintended poisoning demonstrates both seasonal and regional variation, and it is most common during the winter months in cold climates [7]. Morbidity, which is primarily related to late neurocognitive impairment, persists beyond initial stabilization in up to 40 percent of victims [3,8].

Potential sources of CO, other than fires, include poorly functioning heating systems, improperly vented fuel-burning devices (eg, kerosene heaters, charcoal grills, camping stoves [10], gasoline-powered electrical generators [11,12]), and motor vehicles operating in poorly ventilated areas (eg, ice rinks, warehouses, parking garages). CO poisonings following open air exposure to motorboat exhaust have also been reported [13]. In addition, underground electrical cable fires produce large amounts of CO, which can seep into adjacent buildings and homes [14]. An increase in carbon monoxide exposures has been reported to occur in the immediate aftermath of hurricanes [11,15,16].


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Literature review current through: Dec 2016. | This topic last updated: Thu Jan 19 00:00:00 GMT+00:00 2017.
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