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Medline ® Abstracts for References 8,12-14

of 'Cancer of the appendix and pseudomyxoma peritonei'

8
TI
Carcinoid tumors of the vermiform appendix.
AU
Moertel CG, Dockerty MB, Judd ES
SO
Cancer. 1968;21(2):270.
 
AD
PMID
12
TI
Carcinoid tumours of the appendix.
AU
Anderson JR, Wilson BG
SO
Br J Surg. 1985;72(7):545.
 
Appendicular carcinoid tumours in 147 patients are presented. Two patients had evidence of metastatic spread at the time of presentation. Both patients had primary tumours less than 2 cm in diameter. Size remains the most reliable guide to the malignant potential of these tumours. If, after simple appendicectomy, a carcinoid tumour is found with a post-formalin fixation diameter greater than 1.5 cm then a subsequent right hemicolectomy should be considered.
AD
PMID
13
TI
Prognostic indicators for carcinoid neuroendocrine tumors of the gastrointestinal tract.
AU
Rorstad O
SO
J Surg Oncol. 2005;89(3):151.
 
Factors that determine the clinical course and outcome of patients with gastrointestinal (GI) carcinoid tumors are complex and multifaceted. These include the site of origin within the GI tract, the size of the primary tumor, and the anatomical extent of disease, whether localized, regional, or metastatic to distant sites. The new World Health Organization (WHO) histological classification of endocrine tumors, including carcinoids, represents a significant advance in terms of providing a consistent framework for histopathological interpretation that should facilitate multicenter research on treatment outcomes. Histochemical indicators of a poorer prognosis are the degree of expression of the proliferation protein Ki-67 and the p53 tumor suppressor protein. Adverse clinical indicators are the malignant carcinoid syndrome, carcinoid heart disease, and high concentrations of the tumor markers, urinary 5-HIAA and plasma chromogranin A.
AD
Department of Medicine, University of Calgary, Calgary, Alberta, Canada. rorstad@ucalgary.ca
PMID
14
TI
Analysis of 900 appendiceal carcinoid tumors for a proposed predictive staging system.
AU
Landry CS, Woodall C, Scoggins CR, McMasters KM, Martin RC 2nd
SO
Arch Surg. 2008;143(7):664.
 
BACKGROUND: Appendiceal carcinoid tumors (ACTs) are rare, and little is known about the long-term prognosis for these tumors because no staging system exists. Therefore, we sought to investigate prognostic factors associated with ACTs and to create a predictive staging system to accurately estimate prognosis.
HYPOTHESIS: In patients with ACTs, TNM staging will accurately predict prognosis.
DESIGN: Retrospective review of 15 983 patients with carcinoid tumors in the Surveillance Epidemiology and End Results (SEER) database from January 1, 1977, to December 31, 2004.
SETTING: SEER database study.
PARTICIPANTS: Nine hundred patients with ACTs (552 females and 348 males; mean age, 47.1 years [age range, 9-89 years]; mean size of the primary tumor, 2.4 cm [range, 0.1-11.5 cm]). Main Outcome Measure Clinicopathologic features in patients with ACTs that affect prognosis using a newly created TNM staging system incorporating these parameters.
RESULTS: Lymph node metastasis was found in 137 patients (24%), and distant metastatic disease in 89 patients (10%). Stage-specific survival was statistically significant between stages (P<.001) but not within stages. At multivariate analysis, patient age, primary tumor size, histologic features, lymph node involvement, and distant metastasis were significant factors predicting survival.
CONCLUSIONS: Our newly developed TNM staging system accurately predicts prognosis in patients with ACTs. A TNM staging system for ACTs will be helpful not only for physician education about factors that affect the outcome with this disease but also to observe trends in prognosis.
AD
Department of Surgery, Division of Surgical Oncology, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA.
PMID