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Brugada syndrome: Epidemiology and pathogenesis

John V Wylie, MD, FACC
Ann C Garlitski, MD, FACC, FHRS
Section Editors
Scott Manaker, MD, PhD
Samuel Asirvatham, MD
Deputy Editor
Brian C Downey, MD, FACC


The vast majority of cases of sudden cardiac arrest (SCA) and sudden cardiac death (SCD) are caused by ventricular tachyarrhythmias, with most of these associated with structural heart disease, particularly coronary heart disease. SCA in the apparently normal heart is an uncommon occurrence, accounting for only 5 to 10 percent of SCA cases. (See "Pathophysiology and etiology of sudden cardiac arrest".)

Some causes of SCA in patients with apparently normal hearts have been identified and include:

Brugada syndrome

Congenital long QT syndrome (LQTS) (see "Clinical features of congenital long QT syndrome")

Acquired LQTS with polymorphic ventricular tachycardia (VT) (see "Acquired long QT syndrome")


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Literature review current through: Sep 2016. | This topic last updated: Jun 23, 2016.
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