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Brachytherapy for localized prostate cancer

Authors
Mack Roach, III, MD
Steven J DiBiase, MD
Section Editors
Nicholas Vogelzang, MD
W Robert Lee, MD, MS, MEd
Jerome P Richie, MD, FACS
Deputy Editor
Michael E Ross, MD

INTRODUCTION

Standard options for the initial treatment of men with clinically localized prostate cancer (ie, without distant metastases) include radiation therapy (RT; brachytherapy and/or external beam), radical prostatectomy, or in carefully selected patients, active surveillance. The choice of treatment is determined by a variety of factors including patient preference, clinician judgment, and resource availability. (See "Initial approach to low- and very low-risk clinically localized prostate cancer", section on 'Choice of therapy'.)

With brachytherapy, radioactive sources are implanted directly into the prostate gland to administer a high dose of radiation directly to the prostate while minimizing radiation to normal tissues. Observational data indicate that brachytherapy has similar efficacy compared with other forms of radiation and comparable to other modalities (eg, surgery) in the treatment of low-risk prostate cancer, and has an important role in combination with external beam RT in the management of some patients with intermediate and high-risk disease.

The techniques and complications of brachytherapy, along with relevant aspects of patient selection, are reviewed here. The stratification of men with newly diagnosed prostate cancer based upon their risk of local recurrence or dissemination, and the application of these techniques to men with low, intermediate, and high-risk prostate cancer are discussed separately.

(See "Prostate cancer: Risk stratification and choice of initial treatment", section on 'Risk stratification'.)

(See "Initial approach to low- and very low-risk clinically localized prostate cancer".)

                             

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Literature review current through: Nov 2016. | This topic last updated: Wed Jan 27 00:00:00 GMT+00:00 2016.
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