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Medline ® Abstract for Reference 75

of 'Bleomycin-induced lung injury'

Phase II evaluation of bleomycin. A Southwest oncology Group study.
Haas CD, Coltman CA Jr, Gottlieb JA, Haut A, Luce JK, Talley RW, Samal B, Wilson HE, Hoogstraten B
Cancer. 1976 Jul;38(1):8-12.
Bleomycin given intravenously (i.v.) or intramuscularly (i.m.) in twice-weekly doses of 10 mg/m2 was evaluated for efficacy and toxicity in 382 patients. Responses were observed in 11/27 Hodgkin's diseases, 10/30 lymphomas, 9/22 squamous cell cancers of ectodermal origin, 12/26 germinal cancers, and 3/8 renal adenocarcinomas. The i.m. route is less likely to casue pulmonary toxicity or hypotension than the i.v. route. Advanced age and total doses exceeding 200 mg were associated with a higher risk of lung toxicity. All responders had shown at least improvement upon receiving 200 mg; higher total doses should be used only in responding patients.