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Medline ® Abstract for Reference 68

of 'Bleomycin-induced lung injury'

Oxygen-exacerbated bleomycin pulmonary toxicity.
Ingrassia TS 3rd, Ryu JH, Trastek VF, Rosenow EC 3rd
Mayo Clin Proc. 1991 Feb;66(2):173-8.
Bleomycin is an antineoplastic agent with potential for producing pulmonary toxicity, attributed in part to its free radical-promoting ability. Clinical and research experiences have suggested that the risk of bleomycin-induced pulmonary injury is increased with the administration of oxygen. We report a case in which the intraoperative administration of oxygen in the setting of previous bleomycin therapy contributed to postoperative ventilatory failure. Our patient recovered with corticosteroid therapy. Physician awareness of a potential interaction between oxygen and bleomycin may help reduce the morbidity and mortality related to bleomycin therapy.
Division of Thoracic Diseases, Mayo Clinic, Rochester, MN 55905.