Reactivation of bleomycin lung toxicity following oxygen administration. A second response to corticosteroids

Chest. 1985 Aug;88(2):304-6. doi: 10.1378/chest.88.2.304.

Abstract

We report a patient who had two episodes of bleomycin lung toxicity with a good clinical response following corticosteroid therapy. The first episode followed treatment with 120 units of bleomycin and was characterized by cough and dyspnea. The second resulted in ARDS following a surgical procedure that used an FIO2 level of 0.33.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bleomycin / adverse effects*
  • Combined Modality Therapy
  • Cough / chemically induced
  • Drug Synergism
  • Dyspnea / chemically induced
  • Humans
  • Infant, Newborn
  • Lung / drug effects*
  • Male
  • Neoplasms, Germ Cell and Embryonal / complications
  • Neoplasms, Germ Cell and Embryonal / therapy
  • Oxygen / adverse effects*
  • Prednisone / therapeutic use*
  • Respiratory Distress Syndrome, Newborn / chemically induced
  • Testicular Neoplasms / complications
  • Testicular Neoplasms / therapy

Substances

  • Bleomycin
  • Oxygen
  • Prednisone