Beta-lactam antibiotics: Mechanisms of action and resistance and adverse effects
- Stephen B Calderwood, MD
Stephen B Calderwood, MD
- Editor-in-Chief — Infectious Diseases
- Section Editor — Bacterial Infections
- Professor of Medicine (Microbiology and Immunobiology)
- Harvard Medical School
Beta-lactam antibiotics are among the most commonly prescribed drugs, grouped together based upon a shared structural feature, the beta-lactam ring. Beta-lactam antibiotics include:
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- MECHANISM OF ACTION
- MECHANISMS OF BACTERIAL RESISTANCE
- Decreased penetration to the target site
- Alteration of the target site
- Inactivation by a bacterial enzyme
- - Chromosomal beta-lactamases
- - Plasmid-mediated beta-lactamases
- ADVERSE EFFECTS
- IgE-mediated allergic reactions
- Serum sickness
- Dermatologic reactions
- Neurologic reactions
- Pulmonary reactions
- Gastrointestinal reactions
- Hepatobiliary reactions
- Renal reactions
- Hematologic reactions
- INFORMATION FOR PATIENTS