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Barrett's esophagus: Evaluation with autofluorescence endoscopy

Jacques J Bergman, MD, PhD
Section Editor
John R Saltzman, MD, FACP, FACG, FASGE, AGAF
Deputy Editor
Kristen M Robson, MD, MBA, FACG


Barrett's esophagus (BE) is the most important risk factor for esophageal adenocarcinoma, the incidence of which has been rising rapidly over the past few decades. Standard endoscopic imaging provides little detail of the mucosal surface, making it impossible to distinguish specialized intestinal epithelium from gastric-type metaplasia or to recognize dysplastic epithelium.

Better imaging modalities have the potential to improve detection of BE and surveillance for dysplasia and cancer. Many new endoscopic techniques continue to be developed including magnification endoscopy, chromoendoscopy, optical coherence tomography, narrow band imaging, and autofluorescence endoscopy, but none is used routinely in clinical practice.

This topic review will summarize experience with autofluorescence endoscopy. General approaches to diagnosis and management of BE are discussed separately. (See "Barrett's esophagus: Epidemiology, clinical manifestations, and diagnosis" and "Barrett's esophagus: Surveillance and management".)


Several interactions are possible when a photon of light (excitation light) comes into contact with tissue:

The photon may be reflected immediately.

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Literature review current through: Oct 2017. | This topic last updated: Jan 10, 2017.
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