Medline ® Abstract for Reference 91

of 'Bacterial vaginosis'

91
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Comparison of single-dose vs one-week course of metronidazole for symptomatic bacterial vaginosis.
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Swedberg J, Steiner JF, Deiss F, Steiner S, Driggers DA
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JAMA. 1985;254(8):1046.
 
In a prospective, single-blind, randomized study, a single 2-g dose of metronidazole was compared with a seven-day course of 500 mg given twice daily in the treatment of symptomatic vaginal discharge associated with Gardnerella vaginalis. Based on resolution of symptoms and on cultures negative for G vaginalis, 86% (40/46) of women treated with the single dose and 97% (35/36) of women treated with the seven-day course were considered cured at seven to ten days after treatment. Evaluation at 21 days after treatment, however, indicated that only 46% (16/34) of patients treated with the single 2-g dose were considered cured compared with 86% (26/30) of those treated with the seven-day course. Treatment of sexual contacts did not significantly improve cure rates in either group.
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PMID