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Medline ® Abstract for Reference 90

of 'Bacterial vaginosis'

Clindamycin versus metronidazole in the treatment of bacterial vaginosis.
Greaves WL, Chungafung J, Morris B, Haile A, Townsend JL
Obstet Gynecol. 1988;72(5):799.
One hundred forty-three women with complaints of vaginitis were assigned to receive either 500 mg of metronidazole twice daily for 7 days or clindamycin 300 mg twice daily for 7 days. There was no significant difference in the failure rate between patients treated with clindamycin (6.1%) and those treated with metronidazole (4%). Adverse reactions were infrequent and mild in both treatment groups. Three patients who received clindamycin developed non-bloody diarrhea, which was mild and did not necessitate discontinuing therapy. We conclude that clindamycin may be a safe and effective alternative to metronidazole for treating women with bacterial vaginosis.
Division of Infectious Diseases, Howard University Hospital, Washington, DC.