Official reprint from UpToDate®
www.uptodate.com ©2016 UpToDate®

Medline ® Abstract for Reference 122

of 'Bacterial vaginosis'

Bacterial vaginosis diagnosed at the first antenatal visit better predicts preterm labour than diagnosis later in pregnancy.
Schoeman J, Steyn PS, Odendaal HJ, GrovéD
J Obstet Gynaecol. 2005;25(8):751.
This study was conducted as part of a double-blind randomised placebo-controlled trial, the aim of which was to determine whether vitamin C could reduce the recurrence risk of pre-term labour. In this study, women with a history of pre-term labour in a preceding pregnancy were randomised to receive either 250 mg vitamin C or a matching placebo twice daily until 34 weeks' gestation. They attended a dedicated pre-term labour clinic every 2 weeks. All women were screened for bacterial vaginosis (BV) at each visit. It was first determined that vitamin C did not have any effect on the presence of BV. Women who were diagnosed with BV before 20 weeks' gestation were at higher risk of delivering pre-term than those who developed BV after 20 weeks.
Department of Obstetrics and Gynaecology, Tygerberg Hospital, University of Stellenbosch, South Africa. jeannes@sun.ac.za