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Bacterial infections following lung transplantation

Authors
Scott M Palmer, MD, MHS
Aimee Zaas, MD, MHS
Cameron Wolfe, MBBS (Hons)
Section Editors
Elbert P Trulock, MD
Kieren A Marr, MD
Deputy Editor
Anna R Thorner, MD

INTRODUCTION

Lung transplantation is an effective treatment for a wide range of advanced lung diseases. While the survival of lung transplant recipients continues to improve, outcomes after lung transplantation remain inferior to other types of solid organ transplantation [1,2]. Infectious complications contribute substantially to morbidity and mortality following lung transplantation and account for over 25 percent of all posttransplant deaths [2].

This topic reviews the most common bacterial infections in lung transplant recipients. Infections caused by fungi, mycobacteria, and viruses in lung transplant recipients and general issues regarding infections in solid organ transplant recipients are discussed separately. (See "Fungal infections following lung transplantation" and "Tuberculosis in solid organ transplant candidates and recipients" and "Nontuberculous mycobacterial infections in solid organ transplant candidates and recipients" and "Prevention of cytomegalovirus infection in lung transplant recipients" and "Clinical manifestations, diagnosis, and treatment of cytomegalovirus infection in lung transplant recipients" and "Infection in the solid organ transplant recipient" and "Evaluation for infection before solid organ transplantation" and "Prophylaxis of infections in solid organ transplantation" and "Immunizations in solid organ transplant candidates and recipients".)

RISK OF INFECTION

Lung transplant recipients are at increased risk for infectious complications due to the following factors:

The high level of immunosuppression required to prevent rejection

Adverse effects of transplantation on local pulmonary host defenses (loss of lymphatics, reduced mucociliary clearance, decreased cough)

                                   

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Literature review current through: Nov 2016. | This topic last updated: Fri Mar 11 00:00:00 GMT+00:00 2016.
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References
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