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Medline ® Abstract for Reference 5

of 'Atypical fibroxanthoma'

More than 2 decades of treating atypical fibroxanthoma at mayo clinic: what have we learned from 91 patients?
Ang GC, Roenigk RK, Otley CC, Kim Phillips P, Weaver AL
Dermatol Surg. 2009;35(5):765.
BACKGROUND: Atypical fibroxanthoma (AFX) typically occurs on the head and neck of elderly white men. Usually considered a malignancy, it is treated with wide local excision (WLE) or total margin control using Mohs micrographic surgery (MMS).
OBJECTIVE: To determine the most appropriate treatment for this tumor based on a review of cases treated at Mayo Clinic.
METHODS: We reviewed the medical records of patients with AFX treated at Mayo Clinic from 1980 to 2004.
RESULTS: We identified 91 patients with 93 tumors. Treatment information was available for 88 tumors (59 treated with MMS, 23 with WLE, and 6 by other means). There were no recurrences in the patients treated with MMS, with a median follow-up of 4.5 years (range 1.0-16.1 years). Two patients treated with WLE had single recurrences, with a median follow-up of 8.7 years (range 1.5-26.3 years).
CONCLUSIONS: Total microscopic margincontrol using MMS was the most effective means of treating AFX.
Mayo CLinic Rochester, Minnesota 55905, USA.