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Medline ® Abstract for Reference 48

of 'Atypical fibroxanthoma'

Metastasizing atypical fibroxanthoma (cutaneous malignant histiocytoma): report of five cases.
Cooper JZ, Newman SR, Scott GA, Brown MD
Dermatol Surg. 2005 Feb;31(2):221-5; discussion 225.
BACKGROUND: Atypical fibroxanthoma (AFX) is an unusual malignant fibrohistiocytic tumor of sun-damaged skin. When first described, it was felt to be a reactive tumor of low malignant potential. More recently, it has been shown to be a tumor of intermediate malignant potential.
OBJECTIVE: To describe five cases of metastatic AFX.
RESULTS: Five patients ranging in age from 65 to 85 years old presented with metastatic AFX. Three of the five cases presented with regional lymph node disease. Also, three of the five cases had other aggressive cutaneous malignancies. LN-2 (CD74) staining was positive in three of five primary tumors and two of five metastatic tumors.
CONCLUSION: The metastatic potential of AFX may be underestimated. LN-2 staining may be a useful marker in identifying more aggressive tumor behavior.
Department of Dermatology, Division of Otolaryngology, University of Rochester Medical Center, Rochester, New York 14642, USA. jennifer_cooper@urmc.rochester.edu