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Medline ® Abstract for Reference 4

of 'Atypical fibroxanthoma'

4
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Atypical fibroxanthoma: a series of 56 tumors and an unexplained uneven distribution of cases in southeast Germany.
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Wollina U, Schönlebe J, Ziemer M, Friedling F, Koch A, Haroske G, Kaatz M, Simon JC
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Head Neck. 2015 Jun;37(6):829-34.
 
BACKGROUND: Atypical fibroxanthoma is a rare mesenchymal tumor of the head and neck region.
METHODS: We analyzed the files of 3 large dermatology hospitals from the years 2001 to 2013 in southeast Germany.
RESULTS: We identified 53 patients (56 tumors) with a male predominance. The mean age was 78.0 years±8.3 years. Mohs surgery was performed in all cases resulting in complete remission in 45 patients. Five patients had a relapse within 2 years, and 4 developed metastases. None of the tumors with a safety margin of≥2 cm relapsed. The majority of cases were found in the Dresden region.
CONCLUSION: Atypical fibroxanthoma demonstrates an uneven geographic distribution in southeast Germany that demands further investigations. Mohs surgery with≥2 cm safety margins is the treatment of choice. A regular follow-up is recommended.
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Department of Dermatology and Allergology, Hospital Dresden-Friedrichstadt, Academic Teaching Hospital of the Technical University of Dresden, Dresden, Germany.
PMID