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Medline ® Abstract for Reference 4

of 'Atypical fibroxanthoma'

Atypical fibroxanthoma: a series of 56 tumors and an unexplained uneven distribution of cases in southeast Germany.
Wollina U, Schönlebe J, Ziemer M, Friedling F, Koch A, Haroske G, Kaatz M, Simon JC
Head Neck. 2015 Jun;37(6):829-34.
BACKGROUND: Atypical fibroxanthoma is a rare mesenchymal tumor of the head and neck region.
METHODS: We analyzed the files of 3 large dermatology hospitals from the years 2001 to 2013 in southeast Germany.
RESULTS: We identified 53 patients (56 tumors) with a male predominance. The mean age was 78.0 years±8.3 years. Mohs surgery was performed in all cases resulting in complete remission in 45 patients. Five patients had a relapse within 2 years, and 4 developed metastases. None of the tumors with a safety margin of≥2 cm relapsed. The majority of cases were found in the Dresden region.
CONCLUSION: Atypical fibroxanthoma demonstrates an uneven geographic distribution in southeast Germany that demands further investigations. Mohs surgery with≥2 cm safety margins is the treatment of choice. A regular follow-up is recommended.
Department of Dermatology and Allergology, Hospital Dresden-Friedrichstadt, Academic Teaching Hospital of the Technical University of Dresden, Dresden, Germany.