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Medline ® Abstract for Reference 32

of 'Atypical fibroxanthoma'

Immunohistochemical staining of CD10 in atypical fibroxanthomas.
Hultgren TL, DiMaio DJ
J Cutan Pathol. 2007 May;34(5):415-9.
BACKGROUND: The histologic diagnosis of atypical fibroxanthoma (AFX) may be difficult at times with a differential diagnosis including spindle cell/desmoplastic melanoma and a poorly differentiated squamous cell carcinoma (SCC). While there are immunohistochemical stains that may be used to support a diagnosis of either melanoma or carcinoma, the diagnosis of AFX tends to be one of exclusion.
METHODS: A total of 35 cases including 16 AFXs, 10 poorly differentiated SCCs and nine spindle cell/desmoplastic melanomas were stained with the antibody against CD10.
RESULTS: There was strong (3+) diffuse expression of CD10 in 15/16 (94%) AFXs, weak (1+) to moderate (2+) patchy expression of CD10 in 5/10 (50%) SCCs and weak (1+) expression of CD10 in 3/9 (33%) spindle cell/desmoplastic melanomas.
CONCLUSION: CD10 expression is helpful in distinguishing between AFXs, carcinomas and melanomas and will be useful in a panel of antibodies when distinguishing between these entities.
Department of Internal Medicine, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198-3135, USA.