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Medline ® Abstract for Reference 94

of 'Atypical (dysplastic) nevi'

Recurrence of moderately dysplastic nevi with positive histologic margins.
Hiscox B, Hardin MR, Orengo IF, Rosen T, Mir M, Diwan AH
J Am Acad Dermatol. 2017;76(3):527. Epub 2016 Dec 24.
BACKGROUND: The Pigmented Lesion Subcommittee of the Melanoma Prevention Working Group recently published a consensus statement that incompletely excised moderately dysplastic nevi (MDN) without clinical residual pigmentation can be observed and not re-excised. However, data regarding recurrence of MDN with positive histologic margins are quite scant.
OBJECTIVE: We sought to extend the reported findings with a study to determine the recurrence rate of MDN with positive histologic margins.
METHODS: We performed a retrospective study on MDN with positive histologic margins that were not re-excised and for which at least 1 year of clinical follow-up was available.
RESULTS: We found a total of 147 such nevi from January 1, 2007, to December 31, 2013. Six MDN (5 compound and 1 junctional) or 4% recurred with an average recurrence time of 1.7 years. All of these MDN were evaluated by shave biopsies.
LIMITATIONS: Subjectivity in grading of atypia is a limitation of this study.
CONCLUSION: These data from a large study focusing exclusively on recurrence of MDN with positive histologic margins support the conclusion of the Pigmented Lesion Subcommittee that incompletely excised MDN do not require re-excision.
Department of Dermatology, Baylor College of Medicine, Houston, Texas.