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Medline ® Abstract for Reference 92

of 'Atypical (dysplastic) nevi'

The utility of re-excising mildly and moderately dysplastic nevi: a retrospective analysis.
Strazzula L, Vedak P, Hoang MP, Sober A, Tsao H, Kroshinsky D
J Am Acad Dermatol. 2014;71(6):1071.
BACKGROUND: The management of dysplastic nevi (DN) is a highly debated and controversial topic within the dermatology community. Clinicians agree that margin-positive severely DN should be removed with a surgical margin, however, there is disagreement surrounding the appropriate management of margin-positive mildly and moderately DN.
OBJECTIVE: We sought to evaluate the utility of re-excising margin-positive mildly and moderately DN.
METHODS: A retrospective chart review was conducted on all adult patients given the diagnosis of a biopsy-proven DN from 2010 through 2011. The primary outcomes were defined as the presence of melanocytic residuum in re-excisional specimens and a clinically significant change in diagnosis.
RESULTS: A total of 1809 mildly and moderately DN were diagnosed from 2010 through 2011. In all, 765 (42.3%) of these lesions were found to have positive surgical margins during biopsy, and 495 (64.7) of the 765 lesions were subsequently re-excised. Melanocytic residuum waspresent in 18.2% of re-excisional specimens. Re-excision resulted in a clinically significant alteration of the diagnosis in only 1 case (0.2%).
LIMITATIONS: Limitations include retrospective design and inability to assess for malignant transformation given limited follow-up.
CONCLUSIONS: Re-excising mildly and moderately DN results in a low histopathological yield and rarely results in a clinically significant change in diagnosis. As such, clinical monitoring of margin-positive lesions may be warranted.
Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts.