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Medline ® Abstract for Reference 4

of 'Atypical (dysplastic) nevi'

4
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Precursor lesions in familial melanoma. A new genetic preneoplastic syndrome.
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Reimer RR, Clark WH Jr, Greene MH, Ainsworth AM, Fraumeni JF Jr
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JAMA. 1978;239(8):744.
 
In seven consecutive melanoma-prone families, pigmented lesions with distinctive clinical and histologic characteristics occurred in 18 of 20 melanoma patients (90%) and 24 of 43 first-degree relatives (56%). Recognition of these lesions led to the detection of early-stage melanoma in six family members. This syndrome appears to represent an autosomal dominant trait and may serve as a cutaneous marker to identify persons at high risk for melanoma.
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PMID