Medline ® Abstract for Reference 4
of 'Atypical (dysplastic) nevi'
Precursor lesions in familial melanoma. A new genetic preneoplastic syndrome.
Reimer RR, Clark WH Jr, Greene MH, Ainsworth AM, Fraumeni JF Jr
In seven consecutive melanoma-prone families, pigmented lesions with distinctive clinical and histologic characteristics occurred in 18 of 20 melanoma patients (90%) and 24 of 43 first-degree relatives (56%). Recognition of these lesions led to the detection of early-stage melanoma in six family members. This syndrome appears to represent an autosomal dominant trait and may serve as a cutaneous marker to identify persons at high risk for melanoma.