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Medline ® Abstract for Reference 3

of 'Atypical (dysplastic) nevi'

3
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Familial atypical multiple mole-melanoma syndrome.
AU
Lynch HT, Frichot BC 3rd, Lynch JF
SO
J Med Genet. 1978;15(5):352.
 
A family is described showing concordance for malignant melanoma and a cutaneous phenotype characterised by multiple large moles of variable size and colour (reddish-brown to bright red) with pigmentary leakage. Transmission of the cutaneous phenotype in the subject family, and in several others currently under investigation, shows an inheritance pattern consistent with a simple autosomal dominant factor. This cutaneous phenotype signifying melanoma risk may now be added to an increasing body of knowledge dealing with cancer-related genodermatoses.
AD
PMID