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Medline ® Abstracts for References 2-4

of 'Atypical (dysplastic) nevi'

2
TI
Origin of familial malignant melanomas from heritable melanocytic lesions. 'The B-K mole syndrome'.
AU
Clark WH Jr, Reimer RR, Greene M, Ainsworth AM, Mastrangelo MJ
SO
Arch Dermatol. 1978;114(5):732.
 
Distinctive melanocytic moles are described in 37 patients from six melanoma families. Among the family members examined by the authors, 15 of 17 patients with melanoma and 22 of 41 nonmelanoma relatives had the unique moles. The clinical and histological features of these moles have been designated the "B-K mole syndrome." The clinical features of the syndrome include the presence of less than 10 to greater than 100 moles prominent of the upper trunk and extremities, and variability of mole size (5 mm to 15 mm), outline, and color combination. Histologically, B-K moles show atypical melanocytic hyperplasia, lymphocytic infiltration, delicate fibroplasia, and new blood vessels that occur within a compound nevus or de novo. The transformation of two B-K moles into malignant melanomas was documented photographically.
AD
PMID
3
TI
Familial atypical multiple mole-melanoma syndrome.
AU
Lynch HT, Frichot BC 3rd, Lynch JF
SO
J Med Genet. 1978;15(5):352.
 
A family is described showing concordance for malignant melanoma and a cutaneous phenotype characterised by multiple large moles of variable size and colour (reddish-brown to bright red) with pigmentary leakage. Transmission of the cutaneous phenotype in the subject family, and in several others currently under investigation, shows an inheritance pattern consistent with a simple autosomal dominant factor. This cutaneous phenotype signifying melanoma risk may now be added to an increasing body of knowledge dealing with cancer-related genodermatoses.
AD
PMID
4
TI
Precursor lesions in familial melanoma. A new genetic preneoplastic syndrome.
AU
Reimer RR, Clark WH Jr, Greene MH, Ainsworth AM, Fraumeni JF Jr
SO
JAMA. 1978;239(8):744.
 
In seven consecutive melanoma-prone families, pigmented lesions with distinctive clinical and histologic characteristics occurred in 18 of 20 melanoma patients (90%) and 24 of 43 first-degree relatives (56%). Recognition of these lesions led to the detection of early-stage melanoma in six family members. This syndrome appears to represent an autosomal dominant trait and may serve as a cutaneous marker to identify persons at high risk for melanoma.
AD
PMID