Atrial fibrillation in patients with hypertrophic cardiomyopathy
- Martin S Maron, MD
Martin S Maron, MD
- Assistant Professor of Medicine
- Tufts University School of Medicine
- Section Editors
- Samuel Lévy, MD
Samuel Lévy, MD
- Section Editor — Cardiac Arrhythmias
- Professor of Cardiology
- University of Marseille, France
- William J McKenna, MD
William J McKenna, MD
- Section Editor — Myopericardial Disease
- Professor of Cardiology
- University College, London
Hypertrophic cardiomyopathy (HCM) is a genetically determined heart muscle disease most often (60 to 70 percent) caused by mutations in one of several sarcomere genes that encode components of the contractile apparatus. (See "Genetics of hypertrophic cardiomyopathy".)
HCM is characterized by left ventricular hypertrophy (LVH) of various morphologies, with a wide array of clinical manifestations and hemodynamic abnormalities (figure 1). Depending in part upon the site and extent of cardiac hypertrophy, HCM patients can develop one or more of the following abnormalities:
●LV outflow obstruction (see "Types and pathophysiology of obstructive hypertrophic cardiomyopathy")
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- PREDISPOSING FACTORS
- CLINICAL MANIFESTATIONS
- Initial management
- Long-term management
- - Rhythm control
- - Rate control
- - Anticoagulation
- ATRIAL FLUTTER AND OTHER SUPRAVENTRICULAR TACHYCARDIAS
- INFORMATION FOR PATIENTS
- SUMMARY AND RECOMMENDATIONS