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Medline ® Abstract for Reference 39

of 'Association between Helicobacter pylori infection and duodenal ulcer'

Peptic ulcer bleeding in the elderly: relative roles of Helicobacter pylori and non-steroidal anti-inflammatory drugs.
Cullen DJ, Hawkey GM, Greenwood DC, Humphreys H, Shepherd V, Logan RF, Hawkey CJ
Gut. 1997;41(4):459.
BACKGROUND: Most ulcers are caused, one can deduce, by Helicobacter pylori or by use of non-steroidal anti-inflammatory drugs (NSAIDs). Whether both together are worse than one alone is something that is quite unknown.
AIM: To study both factors in order to see wither they interact together positively.
METHOD: A case control study of ulcer bleeding in elderly patients chosen without weeding.
RESULTS: NSAID usage increased risk substantially. So did H pylori infection (but relative risk less than three). Neither seemed to interact. Their actions were discretely intact.
CONCLUSION: H pylori effects ulcer bleeding in an adverse manner but does not make the risk of NSAIDs worse.
Division of Gastroenterology, University Hospital, Nottingham, UK.