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Medline ® Abstract for Reference 36

of 'Association between Helicobacter pylori infection and duodenal ulcer'

Genetic differences between duodenal ulcer patients who were positive or negative for Helicobacter pylori.
Azuma T, Konishi J, Ito Y, Hirai M, Tanaka Y, Ito S, Kato T, Kohli Y
J Clin Gastroenterol. 1995;21 Suppl 1:S151.
This study investigated genetic differences between Helicobacter pylori-positive and -negative duodenal ulcer patients. Seventy-two patients with duodenal ulcer (61 H. pylori positive and 11 H. pylori negative) were examined for HLA-DQA1 genotype. The allele frequency of DQA1*0102 was higher in H. pylori-negative than in H. pylori-positive patients. Moreover, the genotypes that possessed the DQA1*0102 allele were significantly more common in H. pylori-negative than in H. pylori-positive patients. In contrast, the allele frequency of DQA1*0301 was lower in H. pylori-negative than H. pylori-positive patients. The genotypes that possessed DQA1*0301 were significantly more common in H. pylori-positive than in H. pylori-negative patients. These results suggest that there are genetic differences between H. pylori-positive and -negative duodenal ulcer patients and that immunogenetic factors for susceptibility or resistance to H. pylori infection exist in the host.
Second Department of Internal Medicine, Fukui Medical School, Japan.