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Assessment and management of ventricular arrhythmias and sudden death risk in hypertrophic cardiomyopathy

Author
Martin S Maron, MD
Section Editors
Samuel Lévy, MD
William J McKenna, MD
Deputy Editor
Brian C Downey, MD, FACC

INTRODUCTION

Hypertrophic cardiomyopathy (HCM) is a genetic heart muscle disease caused by mutations in one of several sarcomere genes that encode components of the contractile apparatus of the heart. (See "Genetics of hypertrophic cardiomyopathy".)

HCM is characterized by left ventricular hypertrophy (LVH) of various morphologies, with a wide array of clinical manifestations and hemodynamic abnormalities (figure 1). Depending in part upon the site and extent of cardiac hypertrophy, patients with HCM can develop one or more of the following abnormalities:

Left ventricular (LV) outflow obstruction (see "Types and pathophysiology of obstructive hypertrophic cardiomyopathy")

Diastolic and systolic dysfunction

Myocardial ischemia

                    

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Literature review current through: Jun 2015. | This topic last updated: Jun 22, 2015.
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