Medline ® Abstract for Reference 43
of 'Approach to the patient with unintentional weight loss'
Weight Loss in Patients with Dementia: Considering the Potential Impact of Pharmacotherapy.
Franx BAA, Arnoldussen IAC, Kiliaan AJ, Gustafson DR
Drugs Aging. 2017;34(6):425.
Unintentional body weight loss is common in patients with dementia and is linked to cognitive impairment and poorer disease outcomes. It is proposed that some dementia medications with market approval, while aiming to improve cognitive and functional outcomes of a patient with dementia, are associated with reported body weight or body mass index loss. This review presents evidence in the published literature on body weight loss in dementia, describes selected theories behind body weight loss, evaluates the potential impact of approved dementia pharmacotherapies on body weight, considers the potential role for medical foods, understands the potential influence of treatments for neuropsychiatric symptoms and signs, and finally, summarizes this important area.
Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.